Search results for "Sertoli cell-only syndrome"

showing 1 items of 1 documents

New perspectives on the renal slit diaphragm protein podocin.

2011

Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain. Using RT–polymerase chain reaction and immunoblotting followed by sequence analysis, we are for the first time able to prove the expression of a novel podocin isoform (isoform 2), exclusively and constitutively expressed in human podocytes. Furthermore, we reveal singular extrarenal podocin expression in human and murine testis. Our data show the…

Gene isoformAdultMalePathologymedicine.medical_specialtyendocrine systemkidneySertoli cellsBlotting WesternImmunoblottingMolecular Sequence Datatestisurologic and male genital diseasesReal-Time Polymerase Chain ReactionFilamentous actinPathology and Forensic MedicineSertoli cell-only syndromeMiceYoung AdultmedicineAnimalsHumansProtein IsoformsSertoli cell-only syndromeAmino Acid SequenceProhibitinAgedKidneyMicroscopy ConfocalbiologyBase Sequenceurogenital systemPodocytesGene Expression ProfilingIntracellular Signaling Peptides and ProteinsMembrane ProteinsisoformMiddle Agedmedicine.diseaseSertoli cellfemale genital diseases and pregnancy complicationsWT-1medicine.anatomical_structureSlit diaphragmPodocinbiology.proteinOriginal ArticlepodocinModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
researchProduct